While some areas of the brain create more connections, others lose them. We found that the process of forming new memories changes how brain cells are connected to one another. Furthermore, there are approximately 1 billion synapses in the mouse brains researchers often use to study brain function, and they’re all the same opaque to translucent color as the tissue surrounding them.Ī new imaging technique my colleagues and I developed, however, has allowed us to map synapses during memory formation. They’re roughly 10 billion times smaller than the smallest object a standard clinical MRI can visualize. For one, synapses are very small and tightly packed together. But visualizing and mapping synapses is challenging to do. Since then, neuroscientists have attempted to understand the physical changes associated with memory formation. Over 130 years ago, pioneering neuroscientist Santiago Ramón y Cajal first suggested that the brain stores information by rearranging the connections, or synapses, between neurons. USC-Huntington Early Modern Studies InstituteĪll memory storage devices, from your brain to the RAM in your computer, store information by changing their physical qualities. Shinso Ito Center for Japanese Religions and Culture Max Kade Institute for Austrian-German-Swiss Studies Huntington-USC Institute on California and The West Casden Institute for the Study of the Jewish Role in American LifeĬenter for Islamic Thought, Culture and PracticeĬenter for Latinx and Latin American Studies
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